ENTRY       EC 3.4.15.4
NAME        Peptidyl-dipeptidase B
            Dipeptidyl carboxyhydrolase
            Atriopeptin convertase
            Atrial di-(tri-)peptidyl carboxyhydrolase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Peptidyl-dipeptidases
REACTION    Release of C-terminal dipeptide or exceptionally a tripeptide.
SUBSTRATE   Peptide
            H2O
            Artiopeptin III
PRODUCT     Dipeptide
            Peptide
            Artiopeptin I
COFACTOR    Zinc
COMMENT     A membrane-bound, zinc metallopeptidase located in mammalian
            atrial, but not ventricular, myocytes. Although it is capable of
            converting the 126-residue atriopeptin III directly to atriopeptin
            I by releasing a C-terminal tripeptide Phe-Arg-Tyr, it is
            generally restricted to the release of dipeptides. In contrast to
            peptidyl-dipeptidase A (EC 3.4.15.1) it displays no Cl- dependence
            and shows no action on angiotensin I. Conversely, peptidyl-
            -dipeptidase A is unable to release Phe-Arg from C-terminus of
            atriopeptin II.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.15.4
            WIT (What Is There) Metabolic Reconstruction: 3.4.15.4
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