ENTRY       EC 3.4.15.1
NAME        Peptidyl dipeptidase A
            Angiotensin I-converting enzyme
            Kininase II
            Dipeptidyl carboxypeptidase I
            Peptidase P
            Carboxycathepsin
            Dipeptide hydrolase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Peptidyl-dipeptidases
REACTION    Release of a C-terminal dipeptide, -Xaa+Xbb-Xcc, when neither Xaa
            nor Xbb is Pro. Thus, conversion of angiotensin I to angiotensin
            II
SUBSTRATE   Peptide
            Angiotensin I
            Bradykinin
            H2O
PRODUCT     Peptide
            Dipeptide
            Angiotensin II
INHIBITOR   (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-
            $oxoprolyl]glycine benzyl ester
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(acetylthio)methyl-1-
            $oxoprolyl]-(S)-alanine benzyl ester
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-
            $oxoprolyl]glycine
            (S)-N-[3-(3,4-Methylenedioxyphenyl)-2-(mercaptomethyl)-1-
            $oxoprolyl]-(S)-alanine
COFACTOR    Zinc
EFFECTOR    Chloride
COMMENT     A Cl--dependent, zinc glycoprotein that is generally membrane-
            -bound. Active at neutral pH. Only single dipeptides are
            released from angiotensin I and bradykinin because of the lack of
            activity on bonds involving proline. May also have endopeptidase
            activity on some substrates. The enzyme from E. coli was
            formerly EC 3.4.15.3.
DISEASE     MIM: 106180  Dipeptidyl carboxypeptidase-1 (angiotensin I
                         converting enzyme); {Myocardial infarction,
                         susceptibility to} (3)
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
GENES       HSA: DCP1(ACE)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.15.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.15.1
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