ENTRY       EC 3.4.14.5
NAME        Dipeptidyl-peptidase IV
            Dipeptidyl aminopeptidase IV
            Xaa-Pro-dipeptidyl-aminopeptidase
            Gly-Pro naphthylamidase
            Postproline dipeptidyl aminopeptidase IV
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
REACTION    Release of an N-terminal dipeptide, Xaa-Xbb+Xcc, from a
            polypeptide, preferentially when Xbb is Pro, provided Xcc is
            neither Pro nor hydroxyproline
SUBSTRATE   Peptide
            H2O
PRODUCT     Dipeptide
            Polypeptide
INHIBITOR   L-Pro-L-boroPro
COMMENT     A membrane-bound serine-type peptidase in mammals and
            flavobacteria.
            Inhibited L-Pro-L-boroPro ( W.G.Gutheil and W.W.Bachovchin,
            Biochemistry, 32, 8723-8731 (1993) ).
DISEASE     MIM: 102720  Dipeptidylpeptidase IV (CD26; adenosine deaminase
                         complexing
MOTIF       PS: PS00708  D-x(3)-A-x(3)-[LIVMFYW]-x(14)-G-x-S-x-G-G-[LIVMFYW](2)
GENES       HSA: DPP4(CD26)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.14.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.5
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