ENTRY       EC 3.4.14.10
NAME        Tripeptidyl-peptidase II
            Tripeptidyl aminopeptidase
            Tripeptidyl peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
REACTION    Release of an N-terminal tripeptide from a polypeptide
SUBSTRATE   Polypeptide
            H2O
PRODUCT     Tripeptide
            Polypeptide
COMMENT     A cytosolic enzyme active at neutral pH. Inhibited by diisopropyl
            fluorophosphate. Formerly included in EC 3.4.14.8.
DISEASE     MIM: 190470  Tripeptidyl peptidase II
MOTIF       PS: PS00136  [STAIV]-x-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-
                         [DNH]
            PS: PS00137  H-G-[STM]-x-[VC]-[STAG]-[GS]-x-[LIVMA]-[STAGCLV]-[SAGM]
            PS: PS00138  G-T-S-x-[SA]-x-P-x(2)-[STAVC]-[AG]
GENES       HSA: TPP2(Hs.1117)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.14.10
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.10
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