ENTRY       EC 3.4.14.1
NAME        Dipeptidyl-peptidase I
            Cathepsin C
            Dipeptidyl aminopeptidase I
            Dipeptidyl transferase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidyl-peptidases and tripeptidyl-peptidases
REACTION    Release of an N-terminal dipeptide, Xaa-Xbb+Xcc-, except when Xaa
            is Arg or Lys, or Xbb or Xcc is Pro
SUBSTRATE   Peptide
            H2O
PRODUCT     Dipeptide
            Polypeptide
EFFECTOR    Chloride
COMMENT     A Cl--dependent, lysosomal cysteine-type peptidase maximally
            activate at acidic pH. Also polymerizes dipeptide amides,
            arylamides and esters at neutral pH. Formerly EC 3.4.4.9.
MOTIF       PS: PS00139  Q-x(3)-[GE]-x-C-[YW]-x(2)-[STAGC]-[STAGCV]
            PS: PS00639  [LIVMGSTAN]-x-H-[GSACE]-[LIVM]-x-[LIVMAT](2)-G-x-
                         [GSADNH]
            PS: PS00640  [FYCH]-[WI]-[LIVT]-x-[KRQAG]-N-[ST]-W-x(3)-[FYW]-G-
                         x(2)-G-[LFYW]-[LIVMFYG]-x-[LIVMF]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.14.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.14.1
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