ENTRY       EC 3.4.13.9
NAME        X-Pro dipeptidase
            Prolidasese
            Imidodipeptidase
            Proline dipeptidase
            Peptidase D
            gamma-Peptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of Xaa+Pro dipeptides; also acts on aminoacyl-
            hydroxyproline analogues. No action on Pro-Pro
SUBSTRATE   Dipeptide (Xaa-Pro)
            H2O
PRODUCT     Amino acid
            L-Proline
COFACTOR    Manganese
EFFECTOR    Thiol
COMMENT     A Mn2+-activated enzyme, possibly thiol dependent, cytosolic from
            most animal tissues. Formerly EC 3.4.3.7.
DISEASE     MIM: 170100  Peptidase D (prolidase); Prolidase deficiency (3)
MOTIF       PS: PS00491  H-[GYR]-[LIVMT]-[SG]-H-x-[LI]-G-[LIVM]-x-V-H-[DE]
GENES       MJA: MJ0806
            ECO: b3847(pepQ)
            HSA: PEPD(Hs.73947)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.13.9
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.9
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