ENTRY       EC 3.4.13.8
NAME        Pro-X dipeptidase
            Prolyl dipeptidase
            Iminodipeptidase
            Prolinase
            Prolylglycine dipeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Preferential hydrolysis of Pro+Xaa dipeptides; also acts on
            hydroxyprolyl analogues.
SUBSTRATE   Pro-Xaa
            H2O
            Hydroxypro-Xaa
PRODUCT     L-Proline
            Amino acid
            4-Hydroxy-L-proline
COMMENT     Prolyl amino acids are also hydrolysed by cytosol nonspecific
            dipeptidase, EC 3.4.13.18. Earlier reports of action on
            prolyl aminoacyl amides are now attributed to contamination by
            prolyl aminopeptidase. Formerly EC 3.4.3.6.
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.13.8
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.8
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