ENTRY       EC 3.4.13.3
NAME        X-His dipeptidase
            Aminoacylhistidine dipeptidase
            Carnosinase
            Homocarnosinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of Xaa+His dipeptides
SUBSTRATE   Dipeptide
            H2O
            N-Aminoacyl-L-histidine
PRODUCT     beta-Alanine
            L-Histidine
            Amino acid
INHIBITOR   Metal chelating agent
COFACTOR    Zinc
            Manganese
EFFECTOR    Thiol
COMMENT     A mammalian cytosolic enzyme that also acts on acserine and
            homocarnosine (but not on homoanserine), and to a lesser extent on
            some other aminoacyl-L-histidine dipeptides. Activated by thioles;
            inhibited by metal-chelating agents. This enzyme may be identical
            with cytosol nonspecific dipeptidase, EC 3.4.13.18. Formerly
            EC 3.4.3.3 and 3.4.13.13.
PATHWAY     PATH: MAP00252  Alanine and Aspartate metabolism
            PATH: MAP00330  Arginine and proline metabolism
            PATH: MAP00340  Histidine metabolism
            PATH: MAP00410  beta-Alanine metabolism
MOTIF       PS: PS00758  [LI]-[GAL]-[LIVMF]-x-[GSA]-H-x-D-[TV]-[STAV]
            PS: PS00759  [GSTAI]-[SANQ]-D-x-K-[GSACN]-x(2)-[LIVMA]-x(2)-
                         [LIVMFY]-x(14,17)-[LIVM]-x-[LIVMF]-[LIVMSTAG]-[LIVMFA]-
                         x(2)-[DN]-E-E-x-[GSTN]
GENES       ECO: b0237(pepD)
            HIN: HI0675(pepD)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.13.3
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.3
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