ENTRY       EC 3.4.13.20
NAME        beta-Ala-His dipeptidase
            Serum carnosinase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Preferential hydrolysis of the beta-Ala+His dipeptide (carnosine),
            and also anserine, Xaa+His dipeptides and other dipeptides
            including homocarnosine.
SUBSTRATE   Carnosine
            beta-Alanyl-N(pai)-methyl-L-histidine
            Xaa-His
            Homocarnosine
            H2O
PRODUCT     beta-Alanine
            L-Histidine
            N(pai)-Methyl-L-histidine
            Amino acid
            4-Aminobutylate
COFACTOR    Cadmium
            Citrate
COMMENT     Present in the serun of humans and higher primates, but not in the
            serum of other mammals. Activated by Cd2+ and citrate.
PATHWAY     PATH: MAP00340  Histidine metabolism
            PATH: MAP00410  beta-Alanine metabolism
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.13.20
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.20
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