ENTRY       EC 3.4.13.19
NAME        Membrane dipeptidase
            Renal dipeptidase
            Dehydropeptidase I (DPH I)
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of dipeptides
SUBSTRATE   Dipeptide
            H2O
PRODUCT     Amino acid
INHIBITOR   Bestatin
            Cilastatin
COFACTOR    Zinc
COMMENT     A membrane-bound, zinc enzyme with broad specificity. Abundant in
            the kidney cortex. Inhibited by bestatin and cilastatin.
            Formerly EC 3.4.13.11.
DISEASE     MIM: 179780  Dipeptidase-1, renal
MOTIF       PS: PS00869  [LIVM]-E-G-[GA]-x(2)-[LIVMF]-x(6)-L-x(3)-Y-x(2)-G-
                         [LIVM]-R
GENES       HSA: DPEP1(Hs.109)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.13.19
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.19
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