ENTRY       EC 3.4.13.18
NAME        Cytosol non-specific dipeptidase
            Peptidase A
            Glycyl-glycine dipeptidase
            Glycyl-leucine dipeptidase
            N2-beta-Alanylarginine dipeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Dipeptidases
REACTION    Hydrolysis of dipeptides. Hydrophobic dipeptides are cleaved
            preferentially, including prolyl amino acids.
SUBSTRATE   Dipeptide
            H2O
PRODUCT     Amino acid
INHIBITOR   Bestatin
            L-Leucine
COFACTOR    Zinc
EFFECTOR    Dithiothreitol
            Manganese
COMMENT     A zinc enzyme with broad specificity, varying somewhat with
            source species. Activated and stabilized by dithiothreitol and
            Mn2+. Inhibited by bestatin and leucine. Found in bacteria
            (Mycobacterium phlei, E. coli, Streptococcus thermophilus),
            yeast, mouse ascites tumor, rat liver and pig kidney, and pid
            and monkey intestinal mucosa. Formerly EC 3.4.3.1, 3.4.3.2,
            3.4.13.1, 3.4.13.2, 3.4.13.11 and 3.4.13.15.
GENES       HSA: PEPA PEPC
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.13.18
            WIT (What Is There) Metabolic Reconstruction: 3.4.13.18
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