ENTRY       EC 3.4.11.9
NAME        X-Pro aminopeptidase
            Proline aminopeptidase
            Aminopeptidase P
            Aminoacylproline aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of any N-terminal amino acid, including proline, that is
            linked to proline, even from a dipeptide or tripeptide
SUBSTRATE   Peptide
            H2O
PRODUCT     Amino acid
            Prolyl-peptide
COFACTOR    Manganese
COMMENT     A Mn2+-dependent, generally membrane-bound enzyme present in both
            mammalian and bacterial cells.
MOTIF       PS: PS00491  H-[GYR]-[LIVMT]-[SG]-H-x-[LI]-G-[LIVM]-x-V-H-[DE]
GENES       ECO: b2908(pepP)
            HIN: HI0816(pepP)
            MGE: MG324(pepP)
            MPN: P01_orf354(pepP)
            SYN: sll0136(pepP)
            HSA: XPNPEP
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.11.9
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.9
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