ENTRY       EC 3.4.11.5
NAME        Prolyl aminopeptidase
            Proline aminopeptidase
            Pro-X aminopeptidase
            Cytosol aminopeptidase V
            Proline iminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of N-terminal proline from a peptide
SUBSTRATE   Peptide
            H2O
            Polyproline
            Prolyl-2-naphthylamide
PRODUCT     L-Proline
            Peptide
COFACTOR    Manganese
COMMENT     A Mn2+-requiring enzyme present in the cytosol of mammalian and
            microbial cells. In contrast to the mommalian form, the bacterial
            form of the enzyme hydrolyses both polyproline and prolyl-2-
            -naphthylamide. The mammalian enzyme, which is not specific for
            prolyl bonds, is possibly identical with EC 3.4.11.1.
MOTIF       PS: PS00631  N-T-D-A-E-G-R-L
GENES       MGE: MG020(pip)
            MPN: B01_orf309(pip)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.11.5
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.5
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