ENTRY       EC 3.4.11.2
NAME        Membrane alanyl aminopeptidase
            Microsomal aminopeptidase
            Aminopeptidase M
            Aminopeptidase N
            Particle-bound aminopeptidase
            Amino-oligopeptidase
            Alanine aminopeptidase
            Membrane aminopeptidase I
            Pseudo leucine aminopeptidase
            Peptidase E
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of an N-terminal amino acid, Xaa+Xbb- from a peptide,
            amide or arylamide. Xaa is preferably Ala, byt may be most amino
            acids including Pro (slow action). When a terminal hydrophobic
            residue is followed by a prolyl residue, the two may be released
            as an intact Xaa-Pro dipeptide
SUBSTRATE   Peptide
            H2O
            Arylamide
            Amide
PRODUCT     N-Terminal amino acid
            Peptide
COFACTOR    Zinc
COMMENT     A zinc enzyme, not activated by heavy metal ions. Formerly
            EC 3.4.1.2.
DISEASE     MIM: 151530  Alanyl (membrane) aminopeptidase (aminopeptidase N,
                         aminopeptidase M,
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
GENES       ECO: b0932(pepN)
            HIN: HI1614(pepN)
            HSA: ANPEP(PEPN) PEPE
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.11.2
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.2
///