ENTRY EC 3.4.11.18
NAME Methionyl aminopeptidase
Methionine aminopeptidase
Peptidase M
CLASS Hydrolases
Acting on peptide bonds (peptidases)
Aminopeptidases
REACTION Release of N-terminal amino acids, preferentially methionine, from
peptides and arylamides
SUBSTRATE Peptide
Arylamide
H2O
PRODUCT Amino acid
L-Methionine
COMMENT Membrane-bound enzyme present in both prokaryotes and eukaryotes.
Releases methionine from nascent peptides.
MOTIF PS: PS00680 [FY]-x-G-H-G-[LIVMC]-G-x(3)-H-x(2)-P-x-[LIVM]-x-[HN]-
[YW]
GENES MJA: MJ1329
MTH: MTH1296
ECO: b0168(map)
HIN: HI1722(map)
HPY: HP1299
BSU: map
MGE: MG172(map)
MPN: GT9_orf248(map)
SYN: sll0555 slr0786 slr0918
SCE: YBL091C(MAP2) YLR244C(MAP1)
STRUCTURES PDB: 1MAT
DBLINKS University of Geneva ENZYME DATA BANK: 3.4.11.18
WIT (What Is There) Metabolic Reconstruction: 3.4.11.18
SCOP (Structural Classificaion of Proteins): 3.4.11.18
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