ENTRY       EC 3.4.11.1
NAME        Leucyl aminopeptidase
            Leucine aminopeptidase
            Leucyl peptidase
            Peptidase S
            Cytosol aminopeptidase
CLASS       Hydrolases
            Acting on peptide bonds (peptidases)
            Aminopeptidases
REACTION    Release of an N-terminal amino acid, Xaa+Xbb-, in which Xaa is
            preferably Leu, but may be other amino acids including Pro
            although not Arg or Lys, and Xbb may be Pro. Amino acid amides
            and methyl esters are also readily hydrolysed, but rates on
            arylamides are exceedingly low.
SUBSTRATE   Peptide
            H2O
PRODUCT     N-Terminal amino acid
            Peptide
INHIBITOR   Amastatin
COFACTOR    Zinc
EFFECTOR    Heavy metal ion
COMMENT     A zinc enzyme isolated from pig kidney and cattle lens; activated
            by heavy metal ions. Formerly EC 3.4.1.1.
            Inhibited by amastatin ( H.Kim and W.N.Lipscomb, Biochemistry,
            32, 8465-8478 (1993) ).
MOTIF       PS: PS00631  N-T-D-A-E-G-R-L
GENES       ECO: b4260(pepA)
            HIN: HI1705(pepA)
            HPY: HP0570(pepA)
            BSU: yuiE
            MGE: MG391
            MPN: D02_orf445
            SYN: sll2001(lap)
            SCE: YKL103C(APE1)
            HSA: PEPS
STRUCTURES  PDB: 1BLL  1BPM  1BPN  1LAM  1LAN  1LAP  1LCP  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.4.11.1
            WIT (What Is There) Metabolic Reconstruction: 3.4.11.1
            SCOP (Structural Classificaion of Proteins): 3.4.11.1
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