ENTRY       EC 3.3.2.6
NAME        Leukotriene-A4 hydrolase
CLASS       Hydrolases
            Acting on ether bonds
            Ether hydrolases
SYSNAME     (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyicosa-7,9,11,14-tetraenoate
            hydrolase
REACTION    (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoate +
            H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyeicosa-6,8,10,14-
            $tetraenoate
SUBSTRATE   (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoate
            H2O
            4,5-Leukotriene A4
PRODUCT     (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate
            Leukotriene B4
COMMENT     Converts 4,5-leukotriene A4 into leukotriene B4. Highly specific.
            Not identical with EC 3.3.2.3.
PATHWAY     PATH: MAP00590  Prostaglandin and leukotriene metabolism
DISEASE     MIM: 151570  Leukotriene A4 hydrolase
MOTIF       PS: PS00142  [GSTALIVN]-x(2)-H-E-[LIVMFYW]-{DEHRKP}-H-x-
                         [LIVMFYWGSPQ]
GENES       SCE: YNL045W(N2535)
            HSA: LTA4H(Hs.81118)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.3.2.6
            WIT (What Is There) Metabolic Reconstruction: 3.3.2.6
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