ENTRY       EC 3.3.2.3
NAME        Epoxide hydrolase
            Epoxide hydratase
            Arene-oxide hydratase
CLASS       Hydrolases
            Acting on ether bonds
            Ether hydrolases
SYSNAME     Epoxide hydrolase
REACTION    an Epoxide + H2O = a Glycol
SUBSTRATE   Epoxide
            Arene oxide
            H2O
PRODUCT     Glycol
            Arene diol
COMMENT     Acts on a variety of epoxides and arene oxides. Formerly
            EC 4.2.1.63 and 4.2.1.64.
DISEASE     MIM: 132810  Epoxide hydroxylase 1, microsomal (xenobiotic); ?Fetal
                         hydantoin syndrome (1); Diphenylhydantoin toxicity (1)
            MIM: 132811  Epoxide hydrolase 2, cytoplasmic
MOTIF       PS: PS00342  [SAGCN]-[RKH]-[LIVMAF]>
GENES       HSA: EPHX1(EPHX)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.3.2.3
            WIT (What Is There) Metabolic Reconstruction: 3.3.2.3
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