ENTRY       EC 3.2.2.22
NAME        rRNA N-glycosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing N-glycosyl compounds
SYSNAME     rRNA N-glycohydrolase
REACTION    Endohydrolysis of the N-glycosidic bond at one specific
            position in 28S rRNA from rat ribosomes
SUBSTRATE   28S rRNA
            H2O
PRODUCT     rRNA
COMMENT     Ricin A-chain and related toxins show this activity.
            Naked rRNA is attacked more slowly than rRNA in intact
            ribosomes. Naked rRNA from Escherichia coli is cleaved
            at a corresponding position.
MOTIF       PS: PS00275  [LIVMA]-x-[LIVMSTA](2)-x-E-[AGV]-[STAL]-R-[FY]-[RKNQS]-
                         x-[LIVM]-[EQS]-x(2)-[LIVMF]
STRUCTURES  PDB: 1AHA  1AHC  1FMP  1MOM  1OBT  1RTC  1TCS  2AAI  1AHB  1OBS  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.2.2.22
            WIT (What Is There) Metabolic Reconstruction: 3.2.2.22
            SCOP (Structural Classificaion of Proteins): 3.2.2.22
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