ENTRY       EC 3.2.1.62
NAME        Glycosylceramidase
            Phlorizin hydrolase
            Phloretin-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Glycosyl-N-acylsphingosine glycohydrolase
REACTION    Glycosyl-N-acylsphingosine + H2O = a Sugar + N-Acylsphingosine
SUBSTRATE   Glycosyl-N-acylsphingosine
            H2O
            Phlorizin
PRODUCT     Sugar
            N-Acylsphingosine
            Phloretin
            Glucose
COMMENT     Broad specificity (cf. EC 3.2.1.45 and 3.2.1.46). Also hydrolyses
            phlorizin to phloretin and glucose. The intestinal enzyme is a
            complex which also catalyses the reaction of EC 3.2.1.108.
DISEASE     MIM: 223000  Lactase; ?Lactase deficiency, congenital (1); ?Lactase
                         deficiency, adult, 223100 (1)
MOTIF       PS: PS00572  [LIVMFSTC]-[LIVFYS]-[LIV]-[LIVMST]-E-N-G-[LIVMFAR]-
                         [CSAGN]
            PS: PS00653  F-x-[FYWM]-[GSTA]-x-[GSTA]-x-[GSTA](2)-[FYNH]-[NQ]-x-E-
                         x-[GSTA]
DBLINKS     University of Geneva ENZYME DATA BANK: 3.2.1.62
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.62
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