ENTRY       EC 3.2.1.52
NAME        beta-N-Acetylhexosaminidase
            Hexosaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-N-Acetyl-D-hexosaminide N-acetylhexosaminohydrolase
REACTION    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
            residues in N-acetyl-beta-D-hexosaminides
SUBSTRATE   N-Acetyl-beta-D-hexosaminide
            H2O
            N-Acetyl-D-glucosaminide
            N-Acetyl-D-galactosaminide
PRODUCT     N-Acetyl-D-hexosamine
            N-Acetyl-D-glucosamine
            N-Acetyl-D-galactosamine
COMMENT     Acts on N-acetylglucosides and N-acetylgalactosides.
PATHWAY     PATH: MAP00530  Aminosugars metabolism
            PATH: MAP00600  Sphingoglycolipid metabolism
DISEASE     MIM: 268800  Hexosaminidase B (beta polypeptide); Sandhoff disease,
                         infantile, juvenile, and adult forms (3); Spinal
                         muscular atrophy, HEXB-related (3)
            MIM: 272800  Hexosaminidase A (alpha polypeptide); Tay-Sachs
                         disease (3); GM2-gangliosidosis, juvenile, adult (3);
                         [Hex A pseudodeficiency] (1)
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
GENES       HSA: HEXA HEXB(Hs.51043)
STRUCTURES  PDB: 1QBB  1QBA  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.2.1.52
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.52
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