ENTRY       EC 3.2.1.49
NAME        alpha-N-Acetylgalactosaminidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha-N-Acetyl-D-galactosaminide N-acetylgalactosaminohydrolase
REACTION    Hydrolysis of terminal non-reducing N-acetyl-D-galactosamine
            residues in N-acetyl-alpha-D-galactosaminides
SUBSTRATE   N-Acetyl-alpha-D-galactosaminide
            H2O
PRODUCT     N-Acetyl-D-galactosamine
COMMENT     Splits N-acetylgalactosaminyl groups from O-3 of Ser and Thr.
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
DISEASE     MIM: 104170  Acetylgalactosaminidase, alpha-N- (alpha-galactosidase
                         B); Schindler disease (3); Kanzaki disease (3); NAGA
                         deficiency, mild (3)
MOTIF       PS: PS00512  G-[LIVMFY]-x(2)-[LIVMFY]-x-[LIVM]-D-D-x-W-x(3,4)-R-
                         [DNSF]
GENES       HSA: NAGA(D22S674)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.2.1.49
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.49
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