ENTRY       EC 3.2.1.35
NAME        Hyaluronoglucosaminidase
            Hyaluronidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Hyaluronate 4-glycanohydrolase
REACTION    Random hydrolysis of 1,4-linkages between N-acetyl-beta-D-
            glucosamine and D-glucuronate residues in hyaluronate
SUBSTRATE   Hyaluronate
            H2O
            Chondroitin
            Chondroitin 4-sulfate
            Chondroitin 6-sulfate
            Dermatan
PRODUCT     Hyaluronate
COMMENT     Also hydrolyses 1,4-beta-D-glycosidic linkages between N-acetyl-
            galactosamine or N-acetylgalactosamine sulfate and glucuronic acid
            in chondroitin, chondroitin 4- and 6- sulfates and dermatan.
DISEASE     MIM: 600930  Sperm adhesion molecule 1 (PH-20 hyaluronidase, zona
                         pellucida
DBLINKS     University of Geneva ENZYME DATA BANK: 3.2.1.35
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.35
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