ENTRY       EC 3.2.1.3
NAME        Glucan 1,4-alpha-glucosidase
            Glucoamylase
            Amyloglucosidase
            gamma-Amylase
            Lysosomal alpha-glucosidase
            Acid maltase
            Exo-1,4-alpha-glucosidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-alpha-D-Glucan glucohydrolase
REACTION    Hydrolysis of terminal 1,4-linked alpha-D-glucose residues
            successively from non-reducing ends of the chains with release
            of beta-D-glucose
SUBSTRATE   Polysaccharide
            Starch
            Glycogen
            H2O
PRODUCT     beta-D-Glucose
COMMENT     Most forms of the enzyme can rapidly hydrolyse 1,6-alpha-D-
            glucosidic bonds when the next bond in sequence is 1,4, and some
            preparations of this enzyme hydrolyse 1,6- and 1,3-alpha-D-
            glucosidic bonds in other polysaccharides. This entry covers all
            such enzymes acting on polysaccharides more rapidly than on
            oligosaccharides. EC 3.2.1.20 from mammalian intestine can
            catalyse similar reactions.
            (EC 3.2.1.20 alpha-Glucosidase)
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DISEASE     MIM: 232300  Glucosidase, acid alpha-; Glycogen storage disease II
                         (3)
MOTIF       PS: PS00013  {DERK}(6)-[LIVMFWSTAG](2)-[LIVMFYSTAGCQ]-[AGS]-C
            PS: PS00129  [GF]-[LIVM]-W-x-D-M-N-E
            PS: PS00707  G-A-D-[LIVM]-C-G-F-x(3)-[ST]-x(3)-L-C-x-R-W-x(2)-L-G-
                         [SA]-F-x-P-F-x-R-N
            PS: PS00820  [STN]-[GP]-x(1,2)-[DE]-x-W-E-E-x(2)-[GS]
GENES       MJA: MJ1610
            SCE: YIL099W(SGA1) YIR019C(STA1)
STRUCTURES  PDB: 3GLY  1KUM  1AC0  1ACZ  1AGM  1DOG  1GAH  1GAI  1GLM  1KUL  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.2.1.3
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.3
            SCOP (Structural Classificaion of Proteins): 3.2.1.3
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