ENTRY       EC 3.2.1.23
NAME        beta-Galactosidase
            Lactase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     beta-D-Galactoside galactohydrolase
REACTION    Hydrolysis of terminal non-reducing beta-D-galactose residues in
            beta-D-galactosides
SUBSTRATE   beta-D-Galactoside
            alpha-D-Arabinoside
            beta-D-Fucoside
            beta-D-Glucoside
            H2O
PRODUCT     beta-D-Galactose
COMMENT     Some enzymes in this group hydrolyse alpha-L-arabinosides; some
            animal enzymes also hydrolyse beta-D-fucosides and beta-D-
            glucosides. (cf. EC 3.2.1.108 Lactase).
PATHWAY     PATH: MAP00052  Galactose metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00600  Sphingoglycolipid metabolism
DISEASE     MIM: 230500  Galactosidase, beta-1; GM1-gangliosidosis (3);
                         Mucopolysaccharidosis IVB (3)
MOTIF       PS: PS00572  [LIVMFSTC]-[LIVFYS]-[LIV]-[LIVMST]-E-N-G-[LIVMFAR]-
                         [CSAGN]
            PS: PS00608  [DENQF]-[KRVW]-N-H-[AP]-[SAC]-[LIVMF](3)-W-[GS]-x(2,3)-
                         N-E
            PS: PS00653  F-x-[FYWM]-[GSTA]-x-[GSTA]-x-[GSTA](2)-[FYNH]-[NQ]-x-E-
                         x-[GSTA]
            PS: PS00719  N-x-[LIVMFYWD]-R-[STACN](2)-H-Y-P-x(4)-[LIVMFYW](2)-
                         x(3)-[DN]-x(2)-G-[LIVMFYW](4)
GENES       ECO: b0344(lacZ) b3076(ebgA) b3077(ebgC)
            BSU: lacA(yvfN)
            SYN: lacZ) slr1081(ECOLI_328
            HSA: GLB1(Hs.79222)
STRUCTURES  PDB: 1BGM  1BGL  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.2.1.23
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.23
///