ENTRY       EC 3.2.1.22
NAME        alpha-Galactosidase
            Melibiase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     alpha-D-Galactoside galactohydrolase
REACTION    Hydrolysis of terminal, non-reducing alpha-D-galactose residues
            in alpha-D-galactosides, including galactose oligosaccharides,
            galactomannans and galactolipids
SUBSTRATE   Galactose oligosaccharide
            Galactomannan
            Galactolipid
            alpha-D-Fucoside
            H2O
PRODUCT     alpha-D-Galactose
COMMENT     Also hydrolyses alpha-D-fucosides.
PATHWAY     PATH: MAP00052  Galactose metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00600  Sphingoglycolipid metabolism
DISEASE     MIM: 301500  Galactosidase, alpha; Fabry disease (3)
MOTIF       PS: PS00512  G-[LIVMFY]-x(2)-[LIVMFY]-x-[LIVM]-D-D-x-W-x(3,4)-R-
                         [DNSF]
GENES       ECO: b4119(melA)
            BSU: melA
            HSA: GLA(GALA)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.2.1.22
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.22
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