ENTRY       EC 3.2.1.18
NAME        Exo-alpha-sialidase
            Neuraminidase
            Sialidase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     Acylneuraminyl hydrolase
REACTION    Hydrolysis of alpha-2,3-, alpha-2,6- and alpha-2,8- glycosidic
            linkages (at a decreasing rate, respectively) of terminal sialic
            residues in oligosaccharides, glycoproteins, glycolipids,
            colominic acid and synthetic substrates
SUBSTRATE   Oligosaccharide(non-reducing N- or O-acylneuraminyl residue)
            Glycoprotein(non-reducing N- or O-acylneuraminyl residue)
            Glycolipid(non-reducing N- or O-acylneuraminyl residue)
            Colominic acid(non-reducing N- or O-acylneuraminyl residue)
            H2O
PRODUCT     Galactose
            N-Acetylhexosamine
INHIBITOR   2-Deoxy-2,3-dehydro-N-acetylneuraminic acid
COMMENT     The enzyme does not act on 4-O-acetylated sialic acids. An
            endo-alpha-sialidase activity is listed as EC 3.2.1.129. See also
            EC 3.2.1.138.
            Inhibited by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. This
            structure were determined at 2.2 A resolution (Proc.Natl.Acad.
            Sci.USA 90, 9852-56, (1993)).
PATHWAY     PATH: MAP00600  Sphingoglycolipid metabolism
DISEASE     MIM: 256550  Neuraminidase; Sialidosis, type I (3); Sialidosis,
                         type II (3)
GENES       HSA: NEU(sialidase)
STRUCTURES  PDB: 7NN9  1IVD  1IVC  1DIL  1DIM  6NN9  5NN9  4NN9  3NN9  2SIM  
                 2SIL  2BAT  1NSD  1NSC  1NSB  1EUR  1EUS  1EUT  1NNC  1NNB  
                 1NNA  1NN2  1NMB  1NMA  1NCD  1NCC  1NCB  1NCA  1KIT  1IVG  
                 1IVF  1EUU  1INF  1ING  1INH  1INV  1INW  1INX  1INY  1IVB  
                 1IVE  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.2.1.18
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.18
            SCOP (Structural Classificaion of Proteins): 3.2.1.18
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