ENTRY       EC 3.2.1.1
NAME        alpha-Amylase
            Glycogenase
CLASS       Hydrolases
            Glycosidases
            Hydrolysing O-glycosyl compounds
SYSNAME     1,4-alpha-D-Glucan glucanohydrolase
REACTION    Endohydrolysis of 1,4-alpha-D-glucosidic linkages in
            polysaccharides containing three or more 1,4-alpha-linked
            D-glucose units
SUBSTRATE   Starch
            Glycogen
            H2O
            Polysaccharide
PRODUCT     Oligosaccharide
COMMENT     Acts on starch, glycogen and related polysaccharides and
            oligosaccharides in a random manner; reducing groups are
            liberated in the alpha-configuration.
PATHWAY     PATH: MAP00500  Starch and sucrose metabolism
DISEASE     MIM: 104650  Amylase, pancreatic, alpha-2A
            MIM: 104660  Amylase, pancreatic, alpha-2B
            MIM: 104700  Amylase, salivary, alpha-1A
MOTIF       PS: PS00506  H-x-C-G-G-N-V-G-D
            PS: PS00679  G-x-[SA]-G-E-[LIVM]-R-Y-P-S-Y
            PS: PS01072  [LFYT]-x-[DA]-x(2,5)-[DNGSATPHY]-[WYFPDA]-x(4)-[LIV]-
                         x(2)-[GTALV]-x(4,5)-[LIVFYC]-x(2)-G-x-[PGSTA]-x(2,3)-
                         [MFYA]-x-[PGAV]-x(3,10)-[LIVMA]-[STKR]-[RY]-x-[EQ]-x-
                         [STALIVM]
GENES       MJA: MJ1611
            ECO: b1927(amyA) b3571(malS)
            BSU: amyE(amyA)
            HSA: AMY1A(AMY1) AMY1B(AMY1) AMY1C(AMY1) AMY2A(AMY2) AMY2B(AMY2)
STRUCTURES  PDB: 1AMY  1BPL  1HNY  1OSE  1PIF  1PIG  1PPI  1SMD  1VJS  2AAA  
                 2TAA  6TAA  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.2.1.1
            WIT (What Is There) Metabolic Reconstruction: 3.2.1.1
            SCOP (Structural Classificaion of Proteins): 3.2.1.1
///