ENTRY EC 3.1.8.2
NAME Diisopropyl-fluorophosphatase
DFPase
Tabunase
Somanase
Organophosphorus acid anhydrolase
CLASS Hydrolases
Acting on ester bonds
Phosphoric triester hydrolases
SYSNAME Diisopropyl-fluorophosphate fluorohydrolase
REACTION Diisopropyl fluorophosphate + H2O = Diisopropyl phosphate +
Fluoride
SUBSTRATE Diisopropyl fluorophosphate
H2O
PRODUCT Diisopropyl phosphate
Fluoride
INHIBITOR Chelating agent
COFACTOR Divalent cation
COMMENT Acts on phosphorus anhydride bonds (such as phosphorus-halide and
phosphorus-cyanide) in organophosphorus compounds (including)
'nerve gases'). Inhibited by chelating agents; requires divalent
cations. Related to EC 3.1.8.1. Previously listed as EC 3.8.2.1.
DBLINKS University of Geneva ENZYME DATA BANK: 3.1.8.2
WIT (What Is There) Metabolic Reconstruction: 3.1.8.2
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