ENTRY       EC 3.1.8.1
NAME        Aryldialkylphosphatase
            Organophosphate hydrolase
            Paraoxonase
            A-esterase
            Aryltriphosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric triester hydrolases
SYSNAME     Aryltriphosphate dialkylphosphohydrolase
REACTION    an Aryl dialkyl phosphate + H2O =
            Dialkyl phosphate + an Aryl alcohol
SUBSTRATE   Aryl dialkyl phosphate
            H2O
            Ester of phosphonic acid
            Ester of phosphinic acid
INHIBITOR   Chelating agent
COFACTOR    Divalent cation
PRODUCT     Dialkyl phosphate
            Aryl alcohol
COMMENT     Acts on organophosphorus compounds (such as paraoxon) including
            esters of phosponic and phosphinic acids. Inhibited by chelating
            agents; requires divalent cations for activity. Previously
            registered as identical with EC 3.1.1.2.
DISEASE     MIM: 168820  Paraoxonase
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.8.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.8.1
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