ENTRY       EC 3.1.6.8
NAME        Cerebroside-sulfatase
            Arylsulfatase A
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     Cerebroside-3-sulfate 3-sulfohydrolase
REACTION    a Cerebroside 3-sulfate + H2O = a Cerebroside + Sulfate
SUBSTRATE   Cerebroside 3-sulfate
            H2O
            Ascorbate 2-sulfate
PRODUCT     Cerebroside
            Sulfate
            Ascorbate
COMMENT     Hydrolyses galactose-3-sulfate residues in a number of lipids.
            Also hydrolyses ascorbate 2-sulfate and many phenol sulfates.
DISEASE     MIM: 250100  Arylsulfatase A; Metachromatic leukodystrophy (3)
MOTIF       PS: PS00149  G-Y-x-[ST]-x(2)-[LIVMA]-G-K-x(0,1)-[FYW]
            PS: PS00523  [SAP]-[LIVMS]-[CS]-x-P-[STA]-R-x(2)-[LIVMF](2)-T-G
GENES       HSA: ARSA(Hs.88251)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.6.8
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.8
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