ENTRY       EC 3.1.6.4
NAME        N-Acetylgalactosamine-6-sulfatase
            Chondroitinsulfatase
            Chondroitininase
            Galactose-6-sulfate sulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     N-Acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase
REACTION    Hydrolysis of the 6-sulfate groups of the
            N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate
            and of the D-galactose 6-sulfate units of keratan sulfate
SUBSTRATE   Chondroitin sulfate
            Keratan sulfate
            H2O
            N-Acetyl-D-galactosamine 6-sulfate
            D-Galactose 6-sulfate
PRODUCT     Sulfate
DISEASE     MIM: 253000  Galactosamine (N-acetyl)-6-sulfate sulfatase;
                         Mucopolysaccharidosis IVA (3)
MOTIF       PS: PS00149  G-Y-x-[ST]-x(2)-[LIVMA]-G-K-x(0,1)-[FYW]
            PS: PS00523  [SAP]-[LIVMS]-[CS]-x-P-[STA]-R-x(2)-[LIVMF](2)-T-G
GENES       HSA: GALNS(GAS)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.6.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.4
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