ENTRY       EC 3.1.6.2
NAME        Steryl-sulfatase
            Arylsulfatase C
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     Steryl-sulfate sulfohydrolase
REACTION    3beta-Hydroxyandrost-5-en-17-one 3-sulfate + H2O =
            3beta-Hydroxyandrost-5-en-17-one + Sulfate
SUBSTRATE   3beta-Hydroxyandrost-5-en-17-one 3-sulfate
            H2O
            Steryl sulfate
PRODUCT     3beta-Hydroxyandrost-5-en-17-one
            Sulfate
COMMENT     Also acts on some related steryl sulfates.
PATHWAY     PATH: MAP00150  Androgen and estrogen metabolism
DISEASE     MIM: 308100  Steroid sulfatase, microsomal; Ichthyosis, X-linked
                         (3); Placental steroid sulfatase deficiency (3)
MOTIF       PS: PS00149  G-Y-x-[ST]-x(2)-[LIVMA]-G-K-x(0,1)-[FYW]
            PS: PS00523  [SAP]-[LIVMS]-[CS]-x-P-[STA]-R-x(2)-[LIVMF](2)-T-G
GENES       HSA: STS(Hs.79876)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.6.2
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.2
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