ENTRY       EC 3.1.6.14
NAME        N-Acetylglucosamine-6-sulfatase
            Chondroitinsulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     N-Acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase
REACTION    Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine
            6-sulfate units of heparan sulfate and keratan sulfate
SUBSTRATE   N-Acetyl-D-glucosamine 6-sulfate
            Heparan sulfate
            Keratan sulfate
            H2O
PRODUCT     Sulfate
COMMENT     May be identical with EC 3.1.6.11
DISEASE     MIM: 252940  N-acetylglucosamine-6-sulfatase; Sanfilippo syndrome,
                         type D (1)
MOTIF       PS: PS00149  G-Y-x-[ST]-x(2)-[LIVMA]-G-K-x(0,1)-[FYW]
            PS: PS00523  [SAP]-[LIVMS]-[CS]-x-P-[STA]-R-x(2)-[LIVMF](2)-T-G
GENES       HSA: GNS(Hs.2703)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.6.14
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.14
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