ENTRY       EC 3.1.6.13
NAME        Iduronate-2-sulfatase
            Chondroitinsulfatase
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     L-iduronate-2-sulfate 2-sulfohydrolase
REACTION    Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate
            units of dermatan sulfate, heparan sulfate and heparin
SUBSTRATE   L-Iduronate 2-sulfate
            H2O
            Dermatan sulfate
            Heparan sulfate
            Hiparin
PRODUCT     Sulfate
DISEASE     MIM: 309900  Iduronate 2-sulfatase (Hunter syndrome);
                         Mucopolysaccharidosis II (3)
MOTIF       PS: PS00149  G-Y-x-[ST]-x(2)-[LIVMA]-G-K-x(0,1)-[FYW]
            PS: PS00523  [SAP]-[LIVMS]-[CS]-x-P-[STA]-R-x(2)-[LIVMF](2)-T-G
GENES       HSA: IDS(SIDS)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.6.13
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.13
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