ENTRY       EC 3.1.6.12
NAME        N-Acetylgalactosamine-4-sulfatase
            Chondroitinsulfatase
            Chondroitinase
            Arylsulfatase B
CLASS       Hydrolases
            Acting on ester bonds
            Sulfuric ester hydrolases
SYSNAME     N-Acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase
REACTION    Hydrolysis of the 4-sulfate groups of the
            N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate
            and dermatan sulfate
SUBSTRATE   Chondroitin sulfate
            Dermatan sulfate
            H2O
            N-Acetyl-D-glucosamine 4-sulfate
PRODUCT     Chondroitin
            Dermatan
            Sulfate
            N-Acetyl-D-glucosamine
COMMENT     Acts also on N-acetylglucosamine 4-sulfate.
DISEASE     MIM: 253200  Arylsulfatase B; Maroteaux-Lamy syndrome, several
                         forms (3)
MOTIF       PS: PS00149  G-Y-x-[ST]-x(2)-[LIVMA]-G-K-x(0,1)-[FYW]
            PS: PS00523  [SAP]-[LIVMS]-[CS]-x-P-[STA]-R-x(2)-[LIVMF](2)-T-G
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.6.12
            WIT (What Is There) Metabolic Reconstruction: 3.1.6.12
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