ENTRY       EC 3.1.4.47
NAME        Variant-surface-glycoprotein phospholipase C
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Variant-surface-glycoprotein-1,2-didecanoyl-sn-phosphatidyl-
            $inositol inositolphosphohydrolase
REACTION    Variant-surface-glycoprotein 1,2-didecanoyl-sn-phosphatidyl-
            $inositol + H2O = 1,2-Didecanoylglycerol + Soluble variant-
            $surface-glycoprotein
SUBSTRATE   Variant-surface-glycoprotein 1,2-didecanoyl-sn-phosphatidyl-
            $inositol
            H2O
            1,2-Didecanoyl-sn-phosphatidylinositol
PRODUCT     1,2-Didecanoylglycerol
            Soluble variant-surface-glycoprotein
COMMENT     By hydrolysis of the attached glycolipid, releases soluble
            variant-surface-glycoprotein containing phosphoinositol from the
            cell wall of Trypanosoma brucei after cell lysis. Highly specific;
            acts very slowly on free 1,2-didecanoyl-sn-phosphatidylinositol.
            Not identical with EC 3.1.4.50.
MOTIF       PS: PS50007  Phosphatidylinositol-specific phospholipase X-
                         box domain profile
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.4.47
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.47
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