ENTRY EC 3.1.4.45
NAME N-Acetylglucosamine-1-phosphodiester
$ alpha-N-acetylglucosaminidase
alpha-N-Acetylglucosaminyl phosphodiesterase
Lysosomal alpha-N-acetylglucosaminidase
CLASS Hydrolases
Acting on ester bonds
Phosphoric diester hydrolases
SYSNAME Glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose
$ N-acetyl-D-glucosaminylphosphohydrolase
REACTION Glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O =
N-Acetyl-D-glucosamine + Glycoprotein phospho-D-mannose
SUBSTRATE Glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose
H2O
PRODUCT N-Acetyl-D-glucosamine
Glycoprotein phospho-D-mannose
COMMENT Acts on a variety of compounds in which N-acetyl-D-glucosamine is
alpha-linked to a phosphate group, including the biosynthetic
intermediates of the high mannose oligosaccharide components of
some lysosomal enzymes and the products of EC 2.7.8.17.
DBLINKS University of Geneva ENZYME DATA BANK: 3.1.4.45
WIT (What Is There) Metabolic Reconstruction: 3.1.4.45
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