ENTRY       EC 3.1.4.41
NAME        Sphingomyelin phosphodiesterase D
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Sphingomyelin ceramide-phosphohydrolase
REACTION    Sphingomyelin + H2O = Ceramide phosphate + Choline
SUBSTRATE   Sphingomyelin
            H2O
            2-Lysophosphatidylcholine
PRODUCT     Ceramide phosphate
            Choline
            2-Lysophosphatidate
COMMENT     Does not act on phosphatidylcholine, but hydrolyses
            2-lysophosphatidylcholine to choline and 2-lysophosphatidate.
PATHWAY     PATH: MAP00570  Sphingophospholipid biosynthesis
GENES       HSA: SMPD1(Hs.77813)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.4.41
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.41
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