ENTRY       EC 3.1.4.4
NAME        Phospholipase D
            Lipophosphodiesterase II
            Lecithinase D
            Choline phosphatase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Phosphatidylcholine phosphatidohydrolase
REACTION    a Phosphatidylcholine + H2O = Choline + a Phosphatidate
SUBSTRATE   Phosphatidylcholine
            H2O
            Phosphatidyl ester
            Phosphatidylethanolamine
            Phosphatidylserine
            Phosphatidylinositol
PRODUCT     Choline
            Phosphatidate
            Ethanolamine
            Serine
            Inositol
COFACTOR    Zinc
COMMENT     Also acts on other phosphatidyl esters.
PATHWAY     PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00580  Phospholipid degradation
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.4.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.4
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