ENTRY       EC 3.1.4.37
NAME        2',3'-Cyclic-nucleotide 3'-phosphodiesterase
            Cyclic-CMP phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase
REACTION    Nucleoside 2',3'-cyclic phosphate + H2O = Nucleoside 2'-phosphate
SUBSTRATE   Nucleoside 2',3'-cyclic phosphate
            2',3'-cyclic AMP
            2',3'-cyclic UMP
            2',3'-cyclic CMP
            H2O
PRODUCT     Nucleoside 2'-phosphate
            Adenosine 2'-phosphate
            Uridine 2'-phosphate
            Cytidine 2'-phosphate
COMMENT     The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on
            the UMP or CMP derivatives. An enzyme from liver acts on
            2',3'-cyclic CMP more rapidly than on the purine derivatives;
            it also hydrolyses the corresponding 3',5'-cyclic phosphates,
            more slowly. This latter enzyme has been called cyclic-CMP
            phosphodiesterase.
DISEASE     MIM: 123830  2', 3' cyclic nucleotide 3' phosphohydrolase
GENES       HSA: CNP(Hs.75062)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.4.37
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.37
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