ENTRY       EC 3.1.4.3
NAME        Phospholipase C
            Lipophosphodiesterase I
            Lecithinase C
            Clostridium welchii alpha-toxin
            Clostridium oedematiens beta- and gamma-toxins
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Phosphatidylcholine cholinephosphohydrolase
REACTION    a Phosphatidylcholine + H2O = 1,2-Diacylglycerol +
            Choline phosphate
SUBSTRATE   Phosphatidylcholine
            Sphingomyelin
            H2O
PRODUCT     1,2-Diacylglycerol
            Choline phosphate
COFACTOR    Zinc
COMMENT     The bacterial enzyme, which is a zinc protein, also acts on
            shingomyelin and phosphatidylinositol; that from seminal plasma
            does not act on phosphatidylinositol.
PATHWAY     PATH: MAP00260  Glycine, serine and threonine metabolism
            PATH: MAP00561  Glycerolipid metabolism
            PATH: MAP00580  Phospholipid degradation
DISEASE     MIM: 600220  Phospholipase C, gamma 2
                         (phosphatidylyinositol-specific)
            MIM: 600230  Phospholipase C, beta 3
                         (phosphatidylinositol-specific)
MOTIF       PS: PS00384  H-Y-x-[GT]-D-[LIVM]-[DNS]-x-P-x-H-[PA]-x-N
GENES       HSA: PLCB2(Hs.994) PLCG1(PLC1)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.4.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.3
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