ENTRY       EC 3.1.4.17
NAME        3',5'-Cyclic-nucleotide phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     3',5'-Cyclic-nucleotide 5'-nucleotidohydrolase
REACTION    Nucleoside 3',5'-cyclic phosphate + H2O = Nucleoside 5'-phosphate
SUBSTRATE   Nucleoside 3',5'-cyclic phosphate
            3',5'-Cyclic AMP
            3',5'-Cyclic dAMP
            3',5'-Cyclic IMP
            3',5'-Cyclic GMP
            3',5'-Cyclic CMP
            H2O
PRODUCT     Nucleoside 5'-phosphate
            AMP
            dAMP
            IMP
            GMP
            CMP
COMMENT     Act on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP,
            3',5'-cyclic GMP and 3',5'-cyclic CMP.
PATHWAY     PATH: MAP00230  Purine metabolism
DISEASE     MIM: 171891  Phosphodiesterase-1B
            MIM: 600126  phosphodiesterase 4A, cAMP-specific (dunce
                         (Drosophila)-homolog
            MIM: 600127  Phosphodiesterase, 4B, cAMP-specific (dunce
                         (Drosophila)-homolog
            MIM: 600129  Phosphodiesterase 4D, cAMP-specific (dunce
                         (Drosophila)-homolog
            MIM: 600827  Phosphodiesterase 6C, cGMP-specific, cone, alpha prime
MOTIF       PS: PS00126  H-D-[LIVMFY]-x-H-x-[AG]-x(2)-N-x-[LIVMFY]
            PS: PS00607  H-X-H-L-D-H-[LIVM]-x-[GS]-[LIVMA]-[LIVM](2)-x-S-[AP]
GENES       SYN: PDE1) sll0647(YGL248W
            SCE: YGL248W(PDE1) YOR360C(PDE2)
STRUCTURES  PDB: 1LOI  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.4.17
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.17
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