ENTRY       EC 3.1.4.12
NAME        Sphingomyelin phosphodiesterase
            Neutral sphingomyelinase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     Sphingomyelin cholinephosphohydrolase
REACTION    Sphingomyelin + H2O =  N-Acylsphingosine + Choline phosphate
SUBSTRATE   Sphingomyelin
            H2O
            Phosphatidylcholine
PRODUCT     N-Acylsphingosine
            Choline phosphate
COMMENT     Has very little activity on phosphatidylcholine.
PATHWAY     PATH: MAP00570  Sphingophospholipid biosynthesis
DISEASE     MIM: 257200  Sphingomyelin phosphodiesterase-1, acid lysosomal;
                         Niemann-Pick disease, type A (3); Niemann-Pick disease,
                         type B (3)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.4.12
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.12
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