ENTRY       EC 3.1.4.11
NAME        1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase
            Triphosphoinositide phosphodiesterase
CLASS       Hydrolases
            Acting on ester bonds
            Phosphoric diester hydrolases
SYSNAME     1-Phosphatidyl-D-myo-inositol-4,5-bisphosphate
            inositoltrisphosphohydrolase
REACTION    1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate + H2O =
            D-myo-Inositol 1,4,5-trisphosphate + Diacylglycerol
SUBSTRATE   1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
            H2O
            Phosphatidylinositol phosphate
PRODUCT     D-myo-Inositol 1,4,5-trisphosphate
            Diacylglycerol
COMMENT     Also hydrolyses phosphatidylinositol phosphates.
DISEASE     MIM: 172420  Phospholipase C, gamma 1 (formerly subtype 148)
MOTIF       PS: PS00018  D-x-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-
                         [DENQSTAGC]-x(2)-[DE]-[LIVMFYW]
            PS: PS50001  Src homology 2 (SH2) domain profile
            PS: PS50002  Src homology 3 (SH3) domain profile
            PS: PS50003  PH domain profile
            PS: PS50004  C2-domain profile
            PS: PS50007  Phosphatidylinositol-specific phospholipase X-
                         box domain profile
            PS: PS50008  Phosphatidylinositol-specific phospholipase Y-
                         box domain profile
GENES       SCE: YPL268W(PLC1)
STRUCTURES  PDB: 2PLE  2PLD  2ISD  2HSP  1QAT  1QAS  1MAI  1HSQ  1DJZ  1DJY  
                 1DJX  1DJI  1DJH  1DJG  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.4.11
            WIT (What Is There) Metabolic Reconstruction: 3.1.4.11
            SCOP (Structural Classificaion of Proteins): 3.1.4.11
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