ENTRY EC 3.1.31.1
NAME Micrococcal nuclease
Micrococcal endonuclease
CLASS Hydrolases
Acting on ester bonds
Endonucleases active with either ribo- or deoxyribonucleic acids
and producing other than 5'-phosphomonoesters
REACTION Endonucleolytic cleavage to 3'-phosphomononucleotide and
3'-phosphooligonucleotide end-products
SUBSTRATE RNA
H2O
DNA
PRODUCT 3'-Phosphomononucleotide
3'-Phosphooligonucleotide
COMMENT Hydrolyses double- or single-stranded substrate. Similar enzymes:
Chlamydomonas nuclease; Spleen phosphodiesterase; Spleen
endonuclease. Formerly EC 3.1.4.7. cf. EC 3.1.16.1.
(EC 3.1.16.1 Spleen exonuclease)
MOTIF PS: PS01123 D-G-D-T-[LIVM]-x-[LIVM]-x(9)-R-[LIVM]-x(2)-[LIVM]-D-x-
P-E
GENES MJA: MJ1439
MTH: MTH494
STRUCTURES PDB: 1SYC 1SYD 1SYE 1SYB 1SYG 2ENB 2SNM 2SOB 1STY 1STN
1STH 1STG 1STB 1STA 1SNQ 1SNP 1SNO 1SNM 1SND 1SNC
1NUC 1NSN 1KDC 1KDB 1KDA 1ENC 1ENA 1AEX 1SYF
DBLINKS University of Geneva ENZYME DATA BANK: 3.1.31.1
WIT (What Is There) Metabolic Reconstruction: 3.1.31.1
SCOP (Structural Classificaion of Proteins): 3.1.31.1
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