ENTRY       EC 3.1.27.5
NAME        Pancreatic ribonuclease
            RNase
            RNase I
            RNase A
            Pancreatic RNase
            Ribonuclease I
            Endoribonuclease I
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 3'-phosphomononucleotides and
            3'-phosphooligonucleotides ending in Cp or Up with
            2',3'-cyclic phosphate intermediate
SUBSTRATE   RNA
            H2O
PRODUCT     3'-Phosphomononucleotide
            3'-Phosphooligonucleotide
COMMENT     Similar enzymes: Venom RNase; Thiobacillus thioparus RNase;
            Xenopus laevis RNase; Rhizopus oligosporus RNase; Ribonuclease M.
            Formerly EC 2.7.7.16 and 3.1.4.22.
DISEASE     MIM: 131410  Ribonuclease-2 (eosinophil-derived neurotoxin)
MOTIF       PS: PS00127  C-K-x(2)-N-T-F
STRUCTURES  PDB: 9RSA  8RSA  7RSA  2RNS  2RLN  2AAS  1RUV  1RPH  1RPG  1RPF  
                 1ROB  1RNZ  1RNY  1RNX  1RNW  1BEL  1RBD  1RBE  1RBF  1RBG  
                 1RBH  1RBI  1RBJ  1RCA  1RCN  1RNC  1RND  1RNM  1RNN  1RNO  
                 1RNQ  1RNU  1RNV  1RBC  1LSQ  1DFJ  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.27.5
            WIT (What Is There) Metabolic Reconstruction: 3.1.27.5
            SCOP (Structural Classificaion of Proteins): 3.1.27.5
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