ENTRY       EC 3.1.26.4
NAME        Calf thymus ribonuclease H
            Endoribonuclease H (calf thymus)
            RNase H
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 5'-phosphomonoester
SUBSTRATE   RNA
            H2O
PRODUCT     RNA 5'-phosphate
COMMENT     Acts on RNA-DNA hybrids. Similar enzymes are obtained from E.coli,
            chicken embryo, human KB cells, rat liver, Ustilago maydis, human
            leucaemic cells, Saccharomyces cerevisiae (H2), and Tetrahymena
            pyriformis.
MOTIF       PS: PS00141  [LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-
                         [STAPDENQ]-x-[LIVMFSTNC]-x-[LIVMFGTA]
GENES       MJA: MJ0135
            MTH: MTH1023
            ECO: b0183(rnhB) b0214(rnhA)
            HIN: HI0138(rnhA) HI1059(rnhB)
            HPY: HP0661(rnhA) HP1323(rnhB)
            BSU: rnh
            SYN: rnh1) slr0080(rnhA) slr0271(YMR234W slr1130(rhnB)
            SCE: YMR234W(RNH1)
STRUCTURES  PDB: 1RDC  1RBR  1RNH  1RIL  1RDD  1GOB  1GOC  1KVA  1KVB  1KVC  
                 1LAV  1LAW  1GOA  1RBS  2RN2  1RDB  1RDA  1RCH  1RBV  1RBU  
                 1RBT  
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.26.4
            WIT (What Is There) Metabolic Reconstruction: 3.1.26.4
            SCOP (Structural Classificaion of Proteins): 3.1.26.4
///