ENTRY       EC 3.1.26.3
NAME        Ribonuclease III
            RNase O
            RNase D
CLASS       Hydrolases
            Acting on ester bonds
            Endoribonucleases producing 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 5'-phosphomonoester
SUBSTRATE   RNA
            H2O
            Double-stranded DNA
PRODUCT     RNA 5'-phosphate
COMMENT     Cleaves multimeric tRNA precursor at the spacer region; involved
            also in processing of precursor rRNA, hnRNA and early T7-mRNA.
            Also cleaves double-stranded DNA.
MOTIF       PS: PS00517  [DE]-R-L-E-F-L-G-D-[SA]
GENES       ECO: b1804(rnd) b2567(rnc)
            HIN: HI0014(rnc) HI0390(rnd)
            HPY: HP0662
            BSU: rncS(rnc)
            MGE: MG367(rnc)
            MPN: G12_orf282a(rnc)
            SYN: sll0320(rnd) slr0346(rnc) slr1646(rnc)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.26.3
            WIT (What Is There) Metabolic Reconstruction: 3.1.26.3
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