ENTRY       EC 3.1.22.1
NAME        Deoxyribonuclease II
            DNase II
            Pancreatic DNase II
CLASS       Hydrolases
            Acting on ester bonds
            Endodeoxyribonucleases producing other than 5'-phosphomonoesters
REACTION    Endonucleolytic cleavage to 3'-phosphomononucleotide and
            3'-phosphooligonucleotide end-products.
SUBSTRATE   DNA
            H2O
PRODUCT     3'-Phosphomononucleotide
            3'-Phosphooligonucleotide
COMMENT     Preference for double-stranded DNA.  Similar enzymes Crab testis
            DNase; Snail DNase; Slamon testis DNase; Liver acid DNase; Human
            acid DNases of gastric mucosa and cervix.  Formerly EC 3.1.4.6.
GENES       HSA: DNASE2(DNL2)
DBLINKS     University of Geneva ENZYME DATA BANK: 3.1.22.1
            WIT (What Is There) Metabolic Reconstruction: 3.1.22.1
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